Recent Publications


L.S. Moye, K. Siegersma, I. Dripps, W. Witkowski, E. Mangutov, D. Wang, G. Scherrer, A.A. Pradhan*. (2021) “Delta opioid receptor regulation of CGRP dynamics in the trigeminal complex.” Pain. 162(8):2297-2308. *Cover image August 2021.

Z. Bertels, H. Singh, I. Dripps, K. Siegersma, A.F. Tipton, W.D. Witkowski, Z. Sheets, P. Shah, Conway, E. Mangutov, M. Ao, V. Petukhova, B. Karumudi, P.A. Petukhov, S.M. Baca, M.M. Rasenick, A.A. Pradhan. “Neuronal complexity is attenuated in preclinical models of migraine and restored by HDAC6 inhibition.” Elife. 2021 Apr 15;10:e63076.

Z. Bertels, I.J. Dripps, P. Shah, L.S. Moye, A.F. Tipton, K. Siegersma, A.A. Pradhan. “Delta opioid receptors in Nav1.8 expressing peripheral neurons partially regulate the effect of delta agonist in models of migraine and opioid-induced hyperalgesia.” Neurobiol Pain. 2022 Aug-Dec;12:100099.

Z. Bertels, E. Mangutov, C. Conway, K. Siegersma, S. Asif, P. Shah, N. Huck, V.L. Tawfik, A.A. Pradhan*. “Migraine and peripheral pain models show differential alterations in neuronal complexity.” Headache. 2022 Jun 8. *Winner of the Harold G Wolff Award 2022.


C. M. Holton, L.C. Strother, I. Dripps, A. Pradhan, P.J. Goadsby, P.R. Holland. (2020) “ASIC3 blockade inhibits durovascular and nitric oxide-mediated trigeminal pain.” British Journal of Pharmacology 177(11):2478-2486.

C. Saengjaroentham, LC Strother, I Dripps, M. Rayhan S. Jabir, A. Pradhan, PJ Goadsby, PR Holland. (2020) “Differential medication overuse risk of novel anti-migraine therapeutics.” Brain. 143(9):2681-2688.

K.E. Parker, E. Sugiarto, A.M.W. Taylor, A.A. Pradhan, R. Al-Hasani. (2020) “Pain, Motivation, Migraine and the Microbiome: New Frontiers for Opioid systems and Disease.” Molecular Pharmacology. Oct;98(4):433-444.

I.J. Dripps, Z. Bertels, L.S. Moye, A.F. Tipton, K. Siegersma, S.M. Baca, B.L Kieffer, A.A. Pradhan. (2020) “Forebrain delta opioid receptors regulate the response of delta agonist in models of migraine and opioid-induced hyperalgesia.” Scientific Reports. 19;10(1):17629.

K.M. Targowska-Duda, A. Ozawa, Z. Bertels, A. Cippitelli, J.L. Marcus, H.K. Mielke-Maday, G. Zribi, A.N. Rainey, B.L. Kieffer, A.A. Pradhan, L.Toll. (2020) “NOP receptor agonist attenuates nitroglycerin-induced migraine-like symptoms in mice.” Neuropharmacology. 15;170:108029.

Z. Bertels, W.D. Witkowski, S. Asif, K. Siegersma, R.M.van Rijn, A.A. Pradhan. (2020) “A non-convulsant delta-opioid receptor agonist, KNT-127, reduces cortical spreading depression and nitroglycerin-induced allodynia.” Headache 61(1):170-178. *senior corresponding author.


L.S. Moye, A.F. Tipton, I. Dripps, Z. Sheets, A. Crombie, J.D. Violin, A.A Pradhan. (2019) “Delta opioid receptor agonists are effective for multiple types of headache disorders.” Neuropharmacology. 148:77-86.

P. Zhang, L.S. Moye, B.R. Southey, I. Dripps, J.V. Sweedler, A. Pradhan, S.L. Rodriguez-Zas. (2019) “Opioid-Induced Hyperalgesia Is Associated with Dysregulation of Circadian Rhythm and Adaptive Immune Pathways in the Mouse Trigeminal Ganglia and Nucleus Accumbens.” Molecular Neurobiology. 56(12):7929-7949.

A.A. Pradhan, A.F. Tipton, H. Zhang, A. Akbari, S.C. Pandey. (2019) “Effect of Histone Deacetylase Inhibitor on Ethanol Withdrawal-Induced Hyperalgesia in Rats.” International Journal of Neuropsychopharmacology. 1;22(8):523-527. *

Z. Bertels & A.A. Pradhan. (2019) “Emerging Treatment Targets for Migraine and Other Headaches.” Headache. 59 Suppl 2:50-65.

K.D.B Anapindi, N. Yang, E.V. Romanova, S.S. Rubakhin, A. Tipton, I. Dripps, Z. Sheets, J.V. Sweedler, A.A. Pradhan. (2019) “PACAP and other neuropeptides link chronic migraine and opioid-induced hyperalgesia in mouse models.” Molecular and Cellular Proteomics. 18(12):2447-2458.


A.A. Pradhan*, Z. Bertels, S. Akerman. (2018) “Targeted Nitric Oxide Synthase Inhibitors for Migraine Neurotherapeutics.” Neurotherapeutics. 15(2):391-401.

L.S. Moye, M.L. Novack, A.F. Tipton, H. Krishnan, S.C. Pandey, A.A. Pradhan*. (2018) “The development of a mouse model of mTBI-induced post-traumatic migraine, and identification of the delta opioid receptor as a novel therapeutic target.” Cephalalgia. 39(1):77-90.

A. Vicente-Sanchez, I.J. Dripps, A.F. Tipton, H. Akbari, A. Akbari, E.M. Jutkiewicz, A.A. Pradhan*. (2018) “Tolerance to high-internalizing delta opioid receptor agonist is critically mediated by arrestin 2.” British Journal of Pharmacology. 175(14):3050-3059.

H. Jeong, L.S. Moye, B.R. Southey, I. Dripps, A. Hernandez, E.V. Romanova, S.S. Rubakhin, J.V. Sweedler, A.A. Pradhan, S.L. Rodriguez-Zas. (2018) “Gene network dysregulation in the trigeminal ganglia and nucleus accumbens of a model of chronic migraine-associated hyperalgesia.” Frontiers Systems Neuroscience. 2018 Dec 18;12:63.


Ben Aissa M, Tipton AF, Bertels Z, Gandhi R, Moye LS, Novack M, Bennett BM, Wang Y, Litosh V, Lee SH, Gaisina IN, Thatcher GR, Pradhan AA*. (2017) “Soluble guanylyl cyclase is a critical regulator of migraine-associated pain.” Cephalalgia. 38(8):1471-1484. *Cover October 2016 and Winner of the Cephalalgia Award.

Shiwarski DJ, Tipton A, Giraldo MD, Schmidt BF, Gold MS, Pradhan AA, Puthenveedu MA. (2017) “A PTEN-regulated checkpoint regulates surface delivery of delta opioid receptors.” Journal of Neuroscience. Mar 6, epub ahead of print.

L. Segura, A.A. Pradhan*. (2017) “From blast to bench: a translational mini-review of post-traumatic headache.” Journal of Neuroscience Research. Feb 2, epub ahead of print.

L.S. Moye & A.A. Pradhan. (2017) Animal Model of Chronic Migraine-Associated Pain. Current Protocols in Neuroscience. 2017 Jul 5;80:9.60.1-9.60.9.

A. Vicente-Sanchez & A.A. Pradhan. (2017) Ligand directed signaling at the delta opioid receptor. Book Chapter for The Delta Opioid Receptor. To be published by Springer. Jul 9.In Press.


Cahill CM, Walwyn W, Taylor AM, Pradhan AA, Evans CJ.  (2016) Allostatic Mechanisms of Opioid Tolerance Beyond Desensitization and Downregulation. Trends in Pharmacological Sciences. 37(11):963-976.

A. Vicente-Sanchez, L. Segura, A.A. Pradhan*. (2016) The Delta Opioid Receptor Tool Box. Neuroscience. 338:145-159.

A.A. Pradhan*, J. Perroy, W. Walwyn, M. Smith, A. Vicente-Sanchez, L. Segura, A. Bana, B. Kieffer, C. Evans. (2016) Agonist-selective recruitment of arrestin isoforms differentially modify delta opioid receptor function. Journal of Neuroscience. 36(12):3541–3551.

A.F. Tipton, I. Tarash, B. McGuire, A. Charles, A.A. Pradhan*. (2016) The effects of acute and preventive migraine therapies in a mouse model of chronic migraine. Cephalalgia. 36(11)1048-1056.

A. Charles & A.A. Pradhan. (2016) Delta-opioid receptors as targets for migraine therapy. Current Opinion in Neurology. 29(3):314-9.


A.M Taylor, A. Castonguay, A. Ghogha, P. Vayssiere, A.A. Pradhan, L. Xue, S. Mehrabani, J. Wu, P. Levitt, M.C. Olmstead, Y. De Koninck, C.J. Evans, C.M. Cahill. (2015) Neuroimmune Regulation of GABAergic Neurons Within the Ventral Tegmental Area During Withdrawal from Chronic Morphine. Neuropsychopharmacology.  41(4):949-59.

S.L. Bowersox, A.L. Soohoo, D.J. Shiwarski, S. Shulz, A.A. Pradhan, M.A. Puthenveedu. Cell-autonomous tuning of opioid sensitization by Substance P.  (2015) Cell Reports.  10(11):1925-36.

A.A. Pradhan, V.Tawfik, A. Laboy, G Scherrer.  (2015) In vivo techniques to investigate the internalization profile of opioid receptors. Book chapter for Opioid Receptors: Methods and Protocols. Published by Springer Methods in Molecular Biology Series.


A. Taylor, K. Roberts, A.A. Pradhan, W.Walwyn, K. Lutfy, H. Akbari, F.I. Carroll, C.M. Cahill, C.J. Evans.  (2014) Kappa opioid receptor-mediated analgesia is blocked by a delta opioid receptor agonist. British Journal of Pharmacology. 172(2):691-703.

A.A. Pradhan*, M. Smith, J. Zyuzin, and A. Charles. (2014)  Delta Opioid Receptor Agonists Inhibit Migraine-Related Pain, Aversive State, and Cortical Spreading Depression. British Journal of Pharmacology 171(9):2375-84. *senior corresponding author

A.A. Pradhan*, M. Smith, B. McGuire, I. Tarash, C. Evans, and A. Charles. (2014)  Characterization of a Novel Model of Chronic Migraine.  Pain 155(2):269-74. *senior corresponding author